SODIUM-HYDROGEN EXCHANGER ISOFORM-1 INHIBITION: A PROMISING PHARMACOLOGICAL INTERVENTION FOR RESUSCITATION FROM CARDIAC ARREST

Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest

Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%.Upon cardiac arrest, cessation of coronary blood flow rapidly leads to intense myocardial ischemia and activation of the sarcolemmal Na+-H+ exchanger isoform-1 (NHE-1).NHE-1 activation drives Na+ into cardiomyocytes in exchange for H+ wit

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Tuning the Fermi liquid crossover in Sr2RuO4 with uniaxial stress

Abstract We perform nuclear magnetic resonance (NMR) measurements of Charcoal Grey Vase the oxygen-17 Knight shifts for Sr2RuO4, while subjected to uniaxial stress applied along [100] direction.The resulting strain is associated with a strong variation of the temperature and magnetic field dependence of the inferred magnetic response.A quasiparticl

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New transmedia design for traditional film festivals

The disruptive process of transformation in the audiovisual sector were unexpectedly accelerated after the covid-19 pandemic.This caused a rearrangement in the chain of the distribution, exhibition and circulation, restructuring the whole design of film festivals, once considered the launching point of this entire industry and strongly based on spe

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Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers

Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still Wax Essentials cause clinically challenging, sometimes life-threatening situations.There is an urgent need for enhanced anti-HCMV drugs that offer improved efficacy, reduced dosages and options for long-term treatment without risk of t

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